A new twist in malaria drug resistance

first_img Read Full Story Drug resistance is a major public health challenge for malaria treatment and eradication. In new research, Dyann Wirth and colleagues have found new ways that the parasite that causes malaria—Plasmodium falciparum—is able to develop resistance to the antimalarial drug halofuginone over time.It’s been known that P. falciparum develops resistance to antimalarial drugs through genetic mechanisms. Your new research uncovered a new model of how the malaria parasite can also develop resistance through non-genetic means. How did you and your colleagues discover this?Jonathan Herman, an M.D./Ph.D. student in my lab, became interested in understanding the process by which an organism goes from being sensitive to a drug to being resistant. In the past we’d looked at the endpoint—the point at which the organism had already become resistant—but we never followed the organism’s path over time, over generations, to see how resistance developed. Using DNA sequencing, Jon characterized the features of a malaria parasite population over several generations. He essentially ‘followed’ evolution in the test tube.Jon discovered that the mutation that occurs in the malaria parasite—which confers drug resistance—actually wasn’t the first thing that happened. In fact, the first adaption in the parasite was a change in the concentration of an amino acid called proline, which occurred at a much earlier stage in the parasite’s evolutionary process. The parasite floods itself with this amino acid as a way of neutralizing the effect of the drug, in this case, halofuginone.last_img read more

UW-Madison police chief bans ‘Thin Blue Line’ imagery

first_imgMADISON, Wis. (AP) — University of Wisconsin-Madison’s police chief has banned officers from using “Thin Blue Line” imagery while on duty. The move by Chief Kristen Roman follows criticism on social media of a “Thin Blue Line” flag displayed at the police department’s office. The flag, which resembles a U.S. flag but has a blue stripe, is considered a sign of police solidarity, but has also been criticized as a symbol of white supremacy. The Wisconsin State Journal reports that Roman says the flag has been “co-opted” by extremists with “hateful ideologies” and that her department needs to distance itself from the imagery to build trust with the community.last_img

SMC volleyball rallies for cure

first_imgThe Saint Mary’s volleyball team’s annual “Dig for the Cure” has evolved into something more aggressive – and more personal. The team will host the event, now titled “Crush for the Cure,” at 7 p.m. tonight in the Angela Athletic Facility to raise money for a Saint Mary’s alumna and lymphoma patient, Anne Blair Payne. Payne graduated in 2002 as an education major and was a member of Saint Mary’s basketball team for all four years of her time at Saint Mary’s. “She had just come back for a 10-year reunion this past June,” Julie Schroeder-Biek, Saint Mary’s athletic director said. “The next week I got a call that she went for a run and had severe chest pain.” Shortly thereafter, doctors found a large tumor in Payne’s lung they believed to be lung cancer. They said there was little they could do. Even so, Payne’s brother told her she would “crush it” and triumph. After treatment, the tumor shrunk and the doctors discovered that the cancer was not in her lungs, but located in her lymph nodes. “It was a relief, relatively,” Schroeder-Biek said. None of the athletes present at Saint Mary’s during Payne’s career are still enrolled at Saint Mary’s, but Schroeder-Biek said she feels as if she’s watched the “Once a Belle, always a Belle” motto come to life. “The teammates she had then are here for her now,” Schroeder-Biek said. “They hold her hand during [chemotherapy] treatments. When she shaved her head, they were right there with her. They set up a donation website on GoFundMe so that she can pay for the best treatment and take that worry off her mind.” Payne maintains a regular workout routine and uses running as a metaphor for her life in her blog. In an entry from week 15, day 71, Payne recalls that “as [she] passed hikers on the trail, [she] got a surge of energy and unknowingly picked up the pace. It wasn’t something [she] planned on, it just happened. Similar to now and how all the encouragement and support seems to carry [her] along with [her] even realizing it.” Payne updates the online journal daily, to document her journey with cancer. She ends each entry with an inspirational “Lesson of the Day. “She’s handling everything with grace and dignity and embodies true athletic spirit -battling,” Schroeder-Biek said. “She’s positive. She finds something to get her through the day and in doing that, she inspires others. I’m proud of our community for being there for her.” Toni Kuschel, the Belles’ volleyball coach, says that this year the team “wanted to do something that hit close to home and benefited someone we knew.” “Once the issue was brought to my attention, I talked to the girls about it and we decided we wanted to sponsor her in her courageous battle,” Kuschel said. “Not only are we expecting our fans and other teams, but the support is also coming from Anne’s past teammates and other alumni.” The “Crush for the Cure” will feature t-shirts, bracelets, desserts from Sodexo and other concessions. All of the profit will be donated to Payne’s fundraiser. After Schroeder-Biek sent Payne an email about the “Crush It” bracelets she had just ordered, she heard the phone ring. “No caller ID or anything and I pick it up and say hello and no one responds,” Schroeder-Biek said. “It took me a while to realize it was Anne on the line, crying.” People are allowed and encouraged to either donate a fixed amount or to pledge a certain amount per Saint Mary’s kill during the game against Albion, Kuschel said “These are the kind of lifts people need,” Schroeder-Biek. “Raising money matters but support like this is what carries people further than any of us realize.” Payne’s fundraiser is $636 short of its $15,000 goal. For more information, visit http://www.gofundme.com/rwb70#description and htttp://www.facebook.com/EveryoneLovesAnne.last_img read more

Verizon Wireless Expands 3G Wireless Network in Woodstock, Vermont

first_imgVerizon Wireless,To continue to stay ahead of rising demand for wireless voice, 3G multimedia and Internet access in Windsor County, Vermont, Verizon Wireless has expanded its local network. New cell site provides increased wireless voice and 3G data coverage for western portions of Woodstock and along sections of Route 4, as well as the surrounding area. Expanded 3G data coverage in Woodstock lets more customers using notebook computers or smartphones.‘People across Vermont are increasingly relying on smartphones and 3G apps to manage their busy lives and stay connected at home or on-the-go,’ said director for Network Systems Performance for Verizon Wireless, Richard Enright. ‘Our network investment in New England has kept us ahead of consumer trends, provided our customers a 3G advantage and underscored our belief that any mobile device is only as good as the network it runs on. Proactive and sustained investment has made Verizon Wireless the 3G leader in New England and nationwide.’The company has invested more than $60 billion since its inception to increase the wireless voice and data coverage of its national network and to add new 3G services like Mobile Broadband and V CAST. As the carrier with America’s largest and most reliable wireless network, Verizon Wireless cell sites in New England provide 3G wireless data connectivity.Source: Verizon Wireless. 9.23.2010. WOODSTOCK, Vt.–(BUSINESS WIRE)-About Verizon WirelessVerizon Wireless operates the nation’s most reliable and largest wireless voice and 3G data network, serving more than 92 million customers. Headquartered in Basking Ridge, N.J., with 79,000 employees nationwide, Verizon Wireless is a joint venture of Verizon Communications (NYSE, NASDAQ: VZ) and Vodafone (LSE, NASDAQ: VOD). For more information, visit www.verizonwireless.com(link is external). To preview and request broadcast-quality video footage and high-resolution stills of Verizon Wireless operations, log on to the Verizon Wireless Multimedia Library at www.verizonwireless.com/multimedia(link is external).*Verizon Wireless received the highest numerical score among wireless providers in the proprietary J.D. Power and Associates 2010 Wireless Call Quality Performance StudySM’Vol. 1 Study based on 23,373 total responses measuring 4 providers in the Northeast Region (CT, ME, MA, NH, NY, RI, VT) and measures opinions of wireless users about the call quality of their service. Proprietary study results are based on experiences and perceptions of consumers surveyed in July-December 2009. Your experience may vary. Visit jdpower.comlast_img read more

The future of financial services with Mark Meyer

first_imgThe evolution of the workforce and society over the next decade provides a “vein of optimism” for credit unions, says Filene Research Institute CEO Mark Meyer.As government and businesses increasingly struggle to meet the financial needs of consumers—including many who will be swept into the “gig economy” by technological advances and automation—the need for self-help solutions will grow.The cooperative finance model is well-suited to serving that audience, Meyer tells CUNA News Podcast.“There will be a great need for creative financial services solutions to meet that dynamic of what’s going to transpire in the employment pool,” he says. 12SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr continue reading »last_img read more


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Doctors, beaten and harassed, plan silent protest across India

first_imgDoctors withdrew their plan to light candles in homes and hospitals across India, after Prime Minister Narendra Modi’s government promised to ensure their safety against rising violence over fears medical staff are spreading the deadly coronavirus.The Indian Medical Association had planned the silent protest for 9 p.m. on Wednesday, a stark parallel to Modi’s own exercise a few days earlier, when he urged Indians to light lamps to honor and support doctors. Home Minister Amit Shah, Modi’s confidante, appealed to the IMA not to hold even a symbolic protest and assured them of safety and support.“He has assured that government of India will take all necessary steps and come out shortly with relevant legislations to address the safety and dignity of doctors and healthcare givers,” the IMA said in a statement Wednesday. It said it is withdrawing the protest “to maintain the unity and integrity of our country.” While a backlash against doctors has been seen from Australia to the Philippines, it’s proving more widespread and intense in India, where trust in the healthcare system was already low, misinformation is rampant on social media, and tensions are mounting as the country’s strictly enforced 40-day lockdown drags on.Indian doctors over recent weeks have endured campaigns from their neighbors to force them out of apartment buildings, been attacked by a mob while tracing contacts of a coronavirus case through the slums, and have also been stopped by police and beaten with batons on the way back home from an emergency shift.The final straw was an attack on a convoy carrying the body of a doctor who died of Covid-19. Local media published reports on how his family and friends were attacked by mobs wielding sticks and stones as they tried to bury him, and his colleagues broke down on TV as they narrated the ordeal.“IMA has maintained utmost restraint and patience inspite of extreme provocation,” the IMA had previously said, while calling for the protest. “If dignity is denied even in death, our patience and restraint lose their value.”Topics :last_img read more

Advocacy Groups Celebrate Gov. Wolf’s Intellectual Disability/Autism Funding

first_img Press Release,  Round-Up Governor Tom Wolf’s announcement that $260 million in CARES Act funding will be distributed to the providers of services supporting Pennsylvanians with intellectual disabilities and autism was received with praise by advocacy groups.“We will emerge from the COVID-19 crisis strongest if we continue to take care of one another, and that includes vulnerable Pennsylvanians,” said Gov. Wolf. “This funding will help ensure Pennsylvanians with intellectual disabilities or autism receive the high-quality care they deserve, even amid the COVID-19 pandemic. It will also support the hardworking Pennsylvanians who have dedicated their lives to caring for these individuals and provide peace of mind to the families of these individuals.”Richard Edley, President and CEO, Rehabilitation & Community Providers Association (RCPA):“Throughout it all, this administration has shown needed flexibility in both policy administration and financial support, and that truly has made a world of difference for providers and families. This additional funding is absolutely critical because the challenges these agencies face won’t simply disappear when the pandemic ends.”Cherie Brummans, Executive Director, Alliance of Community Service Providers:“The Alliance of Community Service Providers supports and appreciates the allocation of CARES Act funding as this relief is critically important to sustain the services to some of Pennsylvania’s most vulnerable citizens.”Sherri Landis, Executive Director, The Arc of Pennsylvania:“The Arc of Pennsylvania is grateful to Governor Wolf and Secretary Miller for their leadership in allocating CARES funding for individuals with intellectual and developmental disabilities to continue to receive the support and services they need to live and thrive in the community. The $260 million dollars is a lifeline to the 50,000+ individuals with I/DD and their families who live in the community and receive community-based supports and services. Since the outbreak of COVID-19, the community-based system has tirelessly continued to provide individuals with the life-sustaining services in their communities.”Mark Davis, President and CEO, Pennsylvania Advocacy and Resources for Autism and Intellectual Disability (PAR):“The Governor and lawmakers in both chambers have lifted the lives of tens of thousands of our state’s most vulnerable individuals, as well as the Direct Support Professionals (DSPs) who provide the lifesaving care to individuals with ID/A. Our members and the families they serve are enormously grateful.”Patrick DeMico, Executive Director, The Provider Alliance:“Today our members are receiving notice of these essential funds. We are extremely grateful to the Commonwealth for acknowledging the tireless efforts of those supporting people with intellectual disabilities and autism. All have faced challenges and difficulties to sustain services providing needed care and support throughout the pandemic. Our gratitude to all who have advocated with us, and to our partners in government to obtain their support and understanding of the complexities and challenges faced by those with disabilities. We thank and applaud Governor Wolf, DHS leadership, and our lawmakers for their support and action on our behalf.”Ver esta página en español. June 16, 2020 SHARE Email Facebook Twittercenter_img Advocacy Groups Celebrate Gov. Wolf’s Intellectual Disability/Autism Fundinglast_img read more

Daniel Lugay sworn in as senator this morning

first_imgMr Lugay on his way to Parliament this morning.Daniel Lugay who contested the 2009 general elections for the United Workers Party in the Roseau North Constituency was this morning sworn in as a senator when the Second Meeting of the Second Session of the Eighth Parliament commenced at the House of Assembly. The Speaker of the House of Assembly announced that the Opposition Leader had written to the President indicating his wish to revoke Mr Claudius Sanford’s appointment as senator and appoint Daniel Lugay by a letter dated 19th October, 2011.The newly sworn in senator said in Parliament that he will “endeavor to speak the truth in spite of the cost”.He further promised the Parliament that he will speak the “inconvenient truth” on matters related to unemployment, electoral reform, voter identification cards and equal access to the media among others. Opposition Leader Hector John who congratulated Mr Lugay on his new appointment asked him to respect the constitution of Dominica, not to use the resources of Dominica to enrich himself, not to engage in any fraudulent activities and be reminded that he is a servant of the people and not their master.Mr John further advised the newly sworn in senator who he described as a man of integrity whom he has known for 16 years having worked together to “stand on the side of truth, righteousness and justice”.Meantime, Leader of the United Workers Party Mr Ronald Green also rose to congratulate Mr Lugay stating that he knows him to be an energetic, God fearing, family man who is committed to Dominica.Mr Green further stated that Mr Lugay has responded to the call from his constituents to leadership and because he was unfairly defeated at the last general elections he can “truly represent the attitude of never again”.Mr Green also requested full disclosure and inquiry into matters concerning the country and his wish for a fair, balanced and transparent parliament.Former Deputy Leader of the United Workers Party Kalinago native Claudius Sanford has been granted a Fulbright Faculty Development Scholarship, enabling him to study at the University of Arkansas at Fayetteville, where he will pursue a Master’s degree in Economic Policy. Both the Leader of the Opposition and Leader of the United Workers Party congratulated Mr Sanford for his contribution to the party as well as representing his constituents and wished him well in his studies.Dominica Vibes News Share Sharing is caring! Share Sharecenter_img 181 Views   no discussions Tweet LocalNews Daniel Lugay sworn in as senator this morning by: – October 25, 2011last_img read more

Missing diver found dead off the coast of Sanibel Island

first_imgA missing diver was found dead off the coast of Sanibel Island on Wednesday.Coast Guard crews say the unidentified man went diving 18 miles off the coast of the island Wednesday morning but never resurfaced.The first report of the missing diver came in from an 18-foot boat shortly before 11 a.m., according to the Coast Guard.The 52-year-old man’s body was found just after 1 p.m.This story is developing.last_img